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  • Title: [Endo-histological correlation in chronic Helicobacter pylori gastritis].
    Author: Pârlog G, Mihailovici MS.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2010; 114(2):353-8. PubMed ID: 20700966.
    Abstract:
    UNLABELLED: In this study, we analysed the correlations between endoscopic aspects and histopathological changes at the patients with dispeptic simptoms and anti-Helicobacter pylori antibodies, investigated with upper endoscopy. MATERIAL AND METHODS: Our study comprised of 418 patients from Bacău Hospital, in period October 2005 - October 2008. Histopathological diagnosis was correlated with endoscopic aspects. RESULTS: Average age was 55 years, with predominance of woman and rural people, without statistical significance. Histopathological diagnosis of nonatrophic gastritis was found at 211 (50%) patients, atrophic gastritis at 192 (46%) patients, intestinal metaplasia at 108 (26%), low grad intraepithelial neoplasia at 70 (17%), high grad intraepithelial neoplasia, at 4 (1%) patients, neoplasia at 28 (7%). The most severe diagnostic was atrophic gastritis with intraepithelial neoplasia. Our analysis has found nonatrophic gastritis in 211 patients (50%), atrophic gastritis in 192 (46%), intestinal metaplasia in 108 (26%), low grade intraepithelial neoplasia in 70 (17%), high grade intraepithelial neoplasia in 4 (1%), superficial gastric carcinoma in 27 (7%) and one MALT lymphoma. CONCLUSION: There was no correlation between the endoscopical aspects and the histological diagnosis. All histological changes were strongly related to Helicobacter pylori infection. Prospective studies are needed to evaluate whether the eradication of Helicobacter pylori will indeed reduce the risk of gastric cancer.
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