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  • Title: Estradiol binding in the sexually dimorphic nucleus of the preoptic/anterior hypothalamic area of adult male ferrets and in the equivalent region of females.
    Author: Tobet SA, Baum MJ.
    Journal: Brain Res; 1991 Apr 19; 546(2):345-50. PubMed ID: 2070266.
    Abstract:
    A large number of estradiol-concentrating cells were visualized by autoradiography in a subpopulation of large neurons located in and around the sexually dimorphic male nucleus of the preoptic/anterior hypothalamic area (MN-POA/AH) of castrated male ferrets and in a comparable dorsal portion of the POA/AH of ovariectomized females. Considerably fewer estradiol-labelled cells were seen in the non-dimorphic ventral POA/AH nucleus of both sexes. Estrogen binding in cells in or around the MN-POA/AH may contribute to the formation of this sexually dimorphic nucleus in fetal males and may mediate specific estrogen-dependent behavioral functions in adulthood.
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