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  • Title: Preparation of primary amides from functionalized organozinc halides.
    Author: Schade MA, Manolikakes G, Knochel P.
    Journal: Org Lett; 2010 Aug 20; 12(16):3648-50. PubMed ID: 20704410.
    Abstract:
    Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl(2), react smoothly with commercially available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions.
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