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  • Title: Degree of endothelium injury promotes fibroelastogenesis in experimental acute lung injury.
    Author: Chao MC, Garcia CS, de Oliveira MB, Santos RS, Lucas IH, Silva PL, Vieira-Abreu A, de Castro-Faria-Neto HC, Parra-Cuentas ER, Capelozzi VL, Pelosi P, Rocco PR.
    Journal: Respir Physiol Neurobiol; 2010 Sep 30; 173(2):179-88. PubMed ID: 20708719.
    Abstract:
    We tested the hypothesis that at the early phase of acute lung injury (ALI) the degree of endothelium injury may predict lung parenchyma remodelling. For this purpose, two models of extrapulmonary ALI induced by Escherichia coli lipopolysaccharide (ALI-LPS) or cecal ligation and puncture (ALI-CLP) were developed in mice. At day 1, these models had similar degrees of lung mechanical compromise, epithelial damage, and intraperitoneal inflammation, but endothelial lesion was greater in ALI-CLP. A time course analysis revealed, at day 7: ALI-CLP had higher degrees of epithelial lesion, denudation of basement membrane, endothelial damage, elastic and collagen fibre content, neutrophils in bronchoalveolar lavage fluid (BALF), peritoneal fluid and blood, levels of interleukin-6, KC (murine analogue of IL-8), and transforming growth factor-β in BALF. Conversely, the number of lung apoptotic cells was similar in both groups. In conclusion, the intensity of fibroelastogenesis was affected by endothelium injury in addition to the maintenance of epithelial damage and intraperitoneal inflammation.
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