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  • Title: Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates.
    Author: Yuen C, Zheng W, Huang Z.
    Journal: Biosens Bioelectron; 2010 Oct 15; 26(2):580-4. PubMed ID: 20709521.
    Abstract:
    We report on a low-level detection of anti-cancer drug (paclitaxel) in blood plasma using microwave-treated gold (Au) film-polystyrene (PS) beads as surface-enhanced Raman scattering (SERS) substrates. SERS spectra of paclitaxel can be acquired within 10s at a concentration of 1×10(-8) M in blood plasma adsorbed on the modified Au-PS SERS substrates. The concentrations of paclitaxel ranging from 1.0×10(-8) to 1.0×10(-7) M in blood plasma can be well estimated with an accuracy of ∼3.8×10(-9) M using SERS technique. This work shows the promise of applying microwave-modified Au-PS as SERS substrates for rapid and accurate monitoring of the anti-cancer drug in blood plasma for immediate treatment decisions during cancer therapy.
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