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  • Title: The hypothalamic-pituitary-adrenal axis in women with differentiated thyroid cancer.
    Author: Chrisoulidou A, Pazaitou-Panayiotou K, Georgiou E, Boudina M, Lytras K, Iakovou I, Vainas I, Kaltsas G.
    Journal: Endocr Res; 2010; 35(3):137-43. PubMed ID: 20712436.
    Abstract:
    INTRODUCTION: We studied the function of hypothalamic-pituitary-adrenal (HPA) axis in females with differentiated thyroid cancer (DTC) and its sequelae on metabolism and cardiovascular risk. METHODS AND RESULTS: Sixteen women were investigated with (1) morning, evening, and midnight cortisol and adrenocortophic hormone, (2) cortisol after overnight 1 mg dexamethasone suppression test, (3) cortisol after corticotropin releasing hormone test, (4) oral glucose tolerance test with glucose and insulin estimations, and (5) ultrasound for carotid intima media thickness. A matched control group underwent similar investigations. None of the parameters was significantly different between patients and controls. CONCLUSION: Females with DTC have normal HPA-axis function and similar insulin sensitivity and cardiovascular risk compared to controls.
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