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  • Title: A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives.
    Author: Gornall KC, Samosorn S, Tanwirat B, Suksamrarn A, Bremner JB, Kelso MJ, Beck JL.
    Journal: Chem Commun (Camb); 2010 Sep 21; 46(35):6602-4. PubMed ID: 20714562.
    Abstract:
    ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands.
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