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  • Title: A new series of macrolide derivatives with 4''-O-saccharide substituents.
    Author: Xu P, Chen XZ, Liu L, Jin ZP, Lei PS.
    Journal: Bioorg Med Chem Lett; 2010 Sep 15; 20(18):5527-31. PubMed ID: 20716487.
    Abstract:
    A series of novel derivatives of macrolide with 4''-O-mono- or disaccharides were synthesized. The corresponding glycosyl trichloroacetimidates were used as the donors in the glycosylations. The in vitro antibacterial activities of 7a-f and 13-16 against a panel of susceptible and resistant pathogens were tested. The modification of 4''-O-mono- or disaccharides may lead to the understanding of interaction of the macrolide and the bacterial ribosome.
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