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  • Title: ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism.
    Author: Gutte H, Mortensen J, Jensen CV, von der Recke P, Petersen CL, Kristoffersen US, Kjaer A.
    Journal: Clin Physiol Funct Imaging; 2010 Nov; 30(6):466-72. PubMed ID: 20726994.
    Abstract:
    BACKGROUND: The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE). METHODS: Patients suspected of PE had a ventilation/perfusion-single-photon emission-tomography (V/Q-SPECT), pulmonary multidetector computer tomography (MDCT) angiography, blood samples and ECG-gated cardiac CT performed the same day. RESULTS: Pro-ANP, BNP and D-dimer are associated with significantly elevated levels in PE patients with RVD. ROC curves demonstrated that D-dimer, pro-ANP and BNP were accurate for detection of RVD. CONCLUSION: Because measurements of cardiac biomarkers are inexpensive and easily obtained they may prove useful in the clinical diagnosis of RVD. However because of the small sample size, the results need to be confirmed in larger studies.
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