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  • Title: Synthesis and antitumor evaluation of methyl spongoate analogs.
    Author: Jiang CS, Huang CG, Feng B, Li J, Gong JX, Kurtán T, Guo YW.
    Journal: Steroids; 2010 Dec 12; 75(13-14):1153-63. PubMed ID: 20728460.
    Abstract:
    A series of novel methyl spongoate (1) analogs has been synthesized and evaluated for their in vitro cytotoxic properties. It was found that the nature of the C-20 side chain had significant effects on their bioactivities and some analogs showed higher cytotoxicity than 1 against A549, HCT-116, HepG2, SW-1990, MCF-7 and NCI-H460 tumor cell lines. The pharmacological results confirmed that the α,β-unsaturated carbonyl moiety, a Michael acceptor in ring A, plays a pivotal role in the cytotoxic effect of these derivatives. The compiled pharmacological data may be useful for the design of novel analogous anticancer drugs.
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