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  • Title: Stimulatory effect of naloxone on plasma cortisol in human: Possible direct stimulatory action at the adrenal cortex.
    Author: Coiro V, Volpi R, Stella A, Venturi N, Chiodera P.
    Journal: Regul Pept; 2011 Jan 17; 166(1-3):1-2. PubMed ID: 20728478.
    Abstract:
    UNLABELLED: The purpose of the present study was to gain a better insight in the mechanism of naloxone underlying the regulation of adrenal cortisol secretion in humans in vivo; therefore, the stimulatory effect of naloxone on cortisol secretion was assessed in a group of patients with hypothalamo-pituitary disconnection. Patients with hypothalamo-pituitary disconnection because of various pathologies (craniopharingioma, cordoma, suprasellar meningioma, or pituitary macroadenoma) participated in the study. RESULTS: Circulating cortisol, but not adrenocorticotropin (ACTH) levels were significantly higher after naloxone administration than after saline. CONCLUSION: Besides the well-known hypothalamo-pituitary stimulatory action on ACTH release in normal humans, the results of the present study suggest that naloxone exerts direct effects on cortisol secretion at the adrenal gland level; another possibility is that naloxone stimulation of cortisol secretion is mediated by other factor than ACTH.
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