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  • Title: Correlation between imaging features and epithelial cell proliferation in keratocystic odontogenic tumour.
    Author: Ba K, Li X, Wang H, Liu Y, Zheng G, Yang Z, Li M, Shimizutani K, Koseki T.
    Journal: Dentomaxillofac Radiol; 2010 Sep; 39(6):368-74. PubMed ID: 20729187.
    Abstract:
    OBJECTIVES: this study was undertaken to investigate the relationship between radiographic appearance and epithelial cell proliferations in keratocystic odontogenic tumours (KCOTs). METHODS: a retrospective radiographic analysis was performed on 284 cases of KCOT to gain insight into the radiographic characteristics. Expression of Ki-67 in 30 of the 284 cases was detected by the labelled streptavidin-biotin (LSAB) method and evaluated by an image analysis system. RESULTS: the radiographic presentation of KCOT was divided into four types: unilocular, multilocular, multiple and naevoid basal cell carcinoma syndrome (NBCCS). The expression of Ki-67 in NBCCS was significantly different from the solitary and multiple KCOTs (P = 0.018, 0.002). In multilocular KCOTs it was also significantly different from the unilocular and syndrome-associated lesions (P = 0.000). In contrast, no significant differences were observed between the solitary and multiple lesions (P = 0.220). CONCLUSIONS: a high correlation exists in KCOT between its biological behaviour and imaging features. The solitary KCOT seems less biologically aggressive and it should be classified as a cyst rather than a tumour. This means that more than half of KCOTs manifest themselves as ordinary cysts.
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