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  • Title: Organocatalytic synthesis of spiro compounds via a cascade Michael-Michael-aldol reaction.
    Author: Companyó X, Zea A, Alba AN, Mazzanti A, Moyano A, Rios R.
    Journal: Chem Commun (Camb); 2010 Oct 07; 46(37):6953-5. PubMed ID: 20730196.
    Abstract:
    The synthesis of spiro compounds via a Michael-Michael-aldol reaction is reported. The reaction affords spirooxindole derivatives in good yields and in almost diastereo- and enantiopure form. Moreover, the reaction works with several heterocycles such as oxindoles, benzofuranones, pyrazolones or azlactones rendering the final spiro compounds in good yields and excellent stereoselectivities.
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