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  • Title: A highly efficient asymmetric Michael addition of α,α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt.
    Author: Yu F, Jin Z, Huang H, Ye T, Liang X, Ye J.
    Journal: Org Biomol Chem; 2010 Oct 21; 8(20):4767-74. PubMed ID: 20730207.
    Abstract:
    The first highly efficient Michael addition of challenging α,α-disubstituted aldehydes to maleimides catalyzed by a simple bifunctional primary amine thiourea catalyst/benzoic acid system has been successfully developed to generate quaternary carbon centers in high yields (up to 99%) with excellent enantioselectivities (91-99%).
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