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  • Title: [Effect of TT genotype of the vitamin D receptor gene on bone mineral density in dialysis patients].
    Author: Shishkin AN, Mazurenko SO, Aseev MV.
    Journal: Ter Arkh; 2010; 82(6):39-43. PubMed ID: 20731109.
    Abstract:
    AIM: to evaluate the effect of Taqi genotypes of vitamin D receptor (VDR) gene polymorphism on bone mineral density (BMD) and the risk for secondary osteoporosis (OP) in patients on programmed hemodialysis. SUBJECTS AND METHODS: Eighty-two patients treated with long-term hemodialysis were examined. Along with physical examination, osteodensitometry was carried out and VDR gene polymorphism was studied in all the patients. RESULTS: OP in the study skeletal parts was more common in the TT-genotype group. The serum concentration of intact parathyroid hormone and the activity of alkaline phosphatase were also higher in the TT-genotype group. However, the diferences were statistically insignificant between the TT-, Tt-, and tt- genotype groups. BMD was lowest in each study skeletal parts in the TT-genotype group and this difference was statistically significant in the proximal femur, which was estimated by the Z index (p = 0.02). CONCLUSION: The results of the present study confirm the hypothesis that the VRD gene is a genetic determinant of bone metabolism in patients with chronic renal disease who receive long-term hemodialysis.
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