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  • Title: Protein-bound histidine, as well as protein-bound serine, residues are sites of phosphorylation in the synaptic plasma membrane.
    Author: Weller M.
    Journal: Biochim Biophys Acta; 1978 Jun 02; 509(3):491-8. PubMed ID: 207324.
    Abstract:
    When synaptic plasma membrane fragments are incubated with ATP in the presence of Mg2+, phosphate is transferred, not only to protein-bound serine, but also to protein-bound histidine. The phosphorylation of protein-bound serine is stimulated by cyclic AMP and has a Km for ATP of about 0.12 mM, both in the presence and absence of cyclic AMP. By contrast, the phosphorylation of protein-bound histidine is unaffected by cyclic AMP and does not follow Michaelis-Menton kinetics since a non-linear double reciprocal plot is given when activity is measured at various ATP concentrations.
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