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  • Title: Label-free detection of DNA hybridization using surface enhanced Raman spectroscopy.
    Author: Barhoumi A, Halas NJ.
    Journal: J Am Chem Soc; 2010 Sep 22; 132(37):12792-3. PubMed ID: 20738091.
    Abstract:
    The SERS spectrum of DNA is strongly dominated by the strong spectral feature of adenine at 736 cm(-1); the presence of adenine can serve as an endogenous marker for the label-free SERS-based detection of DNA hybridization when the probe DNA sequence is adenine-free. The substitution of 2-aminopurine for adenine on the probe DNA sequence enables the detection of a target sequence using SERS, upon hybridization of the target with the 2-AP-substituted probe DNA sequence.
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