These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents.
    Author: Gugliotta G, Botta M, Tei L.
    Journal: Org Biomol Chem; 2010 Oct 21; 8(20):4569-74. PubMed ID: 20740241.
    Abstract:
    Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-Gd(III) complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.
    [Abstract] [Full Text] [Related] [New Search]