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  • Title: Influence of dietary protein and vitamin B12 on the toxicity and carcinogenicity of aflatoxins in rat liver.
    Author: Temcharoen P, Anukarahanonta T, Bhamarapravati N.
    Journal: Cancer Res; 1978 Jul; 38(7):2185-90. PubMed ID: 207426.
    Abstract:
    The influence of dietary protein content and dietary vitamin B12 supplement on the hepatotoxicity and carcinogenicity of aflatoxin in rat liver was studied. In animals fed a low-protein diet, aflatoxin induced extensive toxic and carcinogenic effects. Cirrhosis was significantly prevented to a certain level by vitamin B12 administration, but the incidence of cholangiofibrosis and hyperplastic nodules was unchanged. No toxic effect was observed in animals receiving high-protein diet with no vitamin B12 supplement in this study (33 weeks). Only one rat bearing a hepatoma was observed in this group. However, hepatoma and hyperplastic nodules were found in the group receiving high-protein diet plus vitamin B12. Cholangiofibrosis and cirrhosis were not observed in the high-protein group regardless of vitamin B12 administration.
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