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  • Title: Effect of indomethacin on materno-fetal amino acid transfer in the dual-perfused human placental cotyledon.
    Author: Krishna BR, King RG, Gu W, Brennecke SP.
    Journal: Reprod Fertil Dev; 1990; 2(5):597-602. PubMed ID: 2075255.
    Abstract:
    Indomethacin (1, 10 and 100 mumol L-1) was incrementally infused (8 min for each concentration) into the maternal and fetal circulations of dual-perfused human placental lobules, and measurements were made of materno-fetal amino acid transfer (using the non-metabolizable amino acid alpha-aminoisobutyric acid, or AIB) and fetal effluent perfusate prostaglandin (PG) E levels. No significant changes in AIB transfer compared with controls were observed at any of the doses of indomethacin infused. There was, however, a significant dose-dependent reduction compared with controls in PGE in the fetal circulation with the infusion of indomethacin.
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