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  • Title: Binding of microtubule proteins to DNA: specificity of the interaction.
    Author: Corces VG, Salas J, Salas ML, Avila J.
    Journal: Eur J Biochem; 1978 May 16; 86(2):473-9. PubMed ID: 207527.
    Abstract:
    Tubulin is detected among the DNA-binding proteins when an extract from fibroblasts is chromatographed on DNA-cellulose. Further purification of the colchicine-binding activity shows that purified tubulin from fibroblasts does not bind to DNA. Depolymerized brain microtubule proteins show a high affinity for DNA. The fraction bound is composed of tubulin and microtubule-associated proteins. Experiments with fractionated microtubule proteins indicate that tubulin-free microtubule associated proteins bind to DNA, while tubulin free of microtubule-associated proteins does not. Microtubule-associated proteins bind better to eukaryotic than to phage DNA suggesting a specificity of the interaction.
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