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  • Title: [Eosinophilic fasciitis (Shulman's syndrome)].
    Author: Iakovleva GI, Venikova MS, Mul'diiarov PIa, Guseva NG.
    Journal: Revmatologiia (Mosk); 1990; (4):3-10. PubMed ID: 2075351.
    Abstract:
    The method of optic and electron microscopy was used to examine the skin, muscle and fascia in 8 patients with eosinophilic fasciitis aged from 20 to 57 years with the disease duration from 6 months to 3.5 years. When examining biopsy samples the authors paid special attention to the state of collagenic structure, cellular elements of the skin connective tissue, fascia and intermuscular layers, changes in the cross-striated muscle adjacent to the fascia, composition of cellular infiltrates as well as to the state of vascular microcirculation. It has been shown that with the given disease one can observe exudative-infiltrative processes with alteration of the vascular bed in the fascia and epimysium and the reaction of the microcirculatory bed of the skin and muscle with subsequent outcome into sclerosis at later periods of the disease. But the morphological data allow exclusion of the diffuse nature of microcirculation derangement in eosinophilic fasciitis. Morphogenesis of vascular lesions in this disease differs from such in scleroderma that suggests two different diseases.
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