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  • Title: Effects of non-steroidal antiphlogistics on mouse ear oedema induced with dithranol.
    Author: Gábor M, Rázga Z.
    Journal: Acta Physiol Hung; 1990; 75(4):287-91. PubMed ID: 2075824.
    Abstract:
    Mouse ear oedema induced with dithranol in mice of the CFLP strain was decreased significantly, in a dose-dependent manner, by the oral administration of the following non-steroids 60 minutes before induction of the oedema: piroxicam, proquazone, azapropazone, nifluminic acid and phenylbutazone. An approximately 50% inhibitory effect could be attained with the following doses: 3.3 mg/kg piroxicam, 5 mg/kg proquazone, 5 mg/kg azapropazone, and 1 mg/kg nifluminic acid. Administration of the largest dose (30 mg/kg) of phenylbutazone, used for comparison, resulted in an oedema decrease of 41%.
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