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  • Title: [Effects of perilymphatic perfusion with cisplatin on the cochlear potential in guinea pigs].
    Author: Wu DZ.
    Journal: Zhonghua Er Bi Yan Hou Ke Za Zhi; 1990 Aug; 25(4):202-4, 254. PubMed ID: 2076322.
    Abstract:
    The effects of three concentrations of cisplatin, administered by acute perilymphatic perfusion on the endocochlear potential (EP) and the cochlear microphonic potential (CM) of the guinea pig cochleae, at 1 kHz are reported. No change in EP magnitude was discovered and a concentration-dependent reduction in CM amplitude occurred during 60 minutes' perfusion period. The results suggest that cisplatin-induced hearing loss is not necessarily progressive degradation of EP.
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