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  • Title: Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy.
    Author: Peterson GM, Boyle RR, Francis HW, Oliver NW, Paterson J, von Witt RJ, Taylor GR.
    Journal: Eur J Clin Pharmacol; 1990; 39(4):419-21. PubMed ID: 2076730.
    Abstract:
    This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were receiving excessive dosages of allopurinol. Consequently, the plasma oxipurinol concentrations were often very high (mean (SD) was 156 (109) mumol.l-1). Accumulation of oxipurinol was inversely related to renal function. Plasma concentrations of oxipurinol and urate were not significantly related. However, most patients with oxipurinol concentrations of up to 100 mumol.l-1 had urate concentrations within the normal reference range.
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