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  • Title: [Bazex's para-neoplastic acrokeratosis. A clinical case with hyperpigmentation].
    Author: Espasandin J, Vignale RA.
    Journal: Med Cutan Ibero Lat Am; 1990; 18(4):257-62. PubMed ID: 2077312.
    Abstract:
    We studied a white skin type 3 male patient aged 68 years old with a paraneoplastic acrokeratosis of Bazex, suffering from an oesophagus neoplasm. Cutaneous manifestations preceded in months the cancer. Dermatosis affected fingers of hands and feet, soles, nose and helix. Black melanic hyperpigmentation was the first cutaneous sign and were followed by an hyperkeratosis, becoming the most clinical characteristic of the syndrome. The sequence of these signs induces us to suggest that hormonal factors elaborated by the tumoral cells are the ones responsible for the pigmentary changes since they appeared before the hyperkeratosis.
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