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  • Title: Delta-6-desaturation of linoleic and alpha-linolenic acids in aged rats: a kinetic analysis.
    Author: Hrelia S, Celadon M, Rossi CA, Biagi PL, Bordoni A.
    Journal: Biochem Int; 1990 Nov; 22(4):659-67. PubMed ID: 2078194.
    Abstract:
    Kinetic parameters of the delta-6-desaturation reaction were determined using both cis-linoleic and alpha-linolenic acid as substrates in liver microsomes of rats of different ages. The Km value for delta-6-desaturation of linoleic acid increased proportionally to the animal age, while the Vm did not change until 25 months of age. The Km values for alpha-linolenic acid were similar in young and senescent rats; on the contrary there was a significant aging influence on the Vm values. The affinity of the enzyme for the (n-3) series substrate was not so influenced by aging as the affinity for the (n-6) series substrate. This loss of affinity may be a key factor in aging through altering the polyunsaturated fatty acid content and distribution into cellular phospholipids.
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