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  • Title: [17 Beta-estradiol interaction with haptoglobin and its complex with hemoglobin].
    Author: Isaeva GM, Smirnov AN, Rozen VB, Beĭsembaeva.
    Journal: Biokhimiia; 1990 Sep; 55(9):1713-6. PubMed ID: 2078644.
    Abstract:
    The estradiol-binding capacity of sheep haptoglobin and its complex with hemoglobin was investigated. It was shown that in the presence of H2O2 the haptoglobin-hemoglobin complex tightly binds 17 beta-estradiol. No dissociation of the estradiol-protein complex occurs after its precipitation with trichloroacetic acid and steroid extraction with the ester. It is supposed that the 17 beta-estradiol is bound to the protein by covalent bonds; this binding is characteristic only of the haptoglobin-hemoglobin complex but not of haptoglobin alone.
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