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  • Title: Distribution of acid phosphatase and beta-glucuronidase in the hypoplastic cerebellum of jaundiced Gunn rats. An enzyme histochemical study.
    Author: Keino H, Sato H, Kashiwamata S.
    Journal: Cell Tissue Res; 1990 Dec; 262(3):515-7. PubMed ID: 2078853.
    Abstract:
    Activities of acid phosphatase and beta-glucuronidase in the cerebella of young jaundiced (j/j) and non-jaundiced (j/+; control) Gunn rats were studied with the enzyme histochemical method. The cerebellum of j/+ rats showed high acid phosphatase activities in Purkinje cells and neurons in the cerebellar nuclei. In j/j rats, a number of neurons were lost and numerous microglialike cells with a high acid phosphatase activity appeared in the hypoplastic cerebellum. Although beta-glucuronidase activity was rarely detected in the control cerebellum, a high enzyme activity was observed associated with microglialike cells in j/j rats. The present results provide a cytological basis for the reported differential increase in the activities of these lysosomal enzymes in the j/j rat cerebellum.
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