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  • Title: Alcoholism and depression: a placebo controlled study with viloxazine.
    Author: Altamura AC, Mauri MC, Girardi T, Panetta B.
    Journal: Int J Clin Pharmacol Res; 1990; 10(5):293-8. PubMed ID: 2079386.
    Abstract:
    Depressive disorders are frequently associated with alcohol abuse. Though many studies have been carried out to clarify the role of antidepressant drugs in the management of alcoholic patients, the data are controversial. The present placebo-controlled study was planned to assess the antidepressant and attenuating drinking-behaviour efficacy of viloxazine (400 mg per os daily) versus a placebo in 30 dysthymic patients affected by alcohol dependence. The results significantly favour viloxazine treatment in alleviating depression and in reducing alcohol abuse. All patients showed baseline haematochemical evidence of liver dysfunction that did not change significantly during the treatment.
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