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  • Title: Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.
    Author: Ye Z, Qian P, Lv G, Luo F, Cheng J.
    Journal: J Org Chem; 2010 Sep 03; 75(17):6043-5. PubMed ID: 20795749.
    Abstract:
    A palladium-catalyzed addition of arylboronic acids to phthalaldehyde, followed by an intramolecular lactonization to access 3-substituted phthalides, is described. The procedure tolerates a series of functional groups, such as methoxyl, fluoro, chloro, and trifluoromethyl groups. It represents a procedure for the synthesis of 3-substituted phthalides.
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