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  • Title: Neonatal community-acquired pneumonia: pathogens and treatment.
    Author: Wang H, Tang J, Xiong Y, Li X, Gonzalez F, Mu D.
    Journal: J Paediatr Child Health; 2010 Nov; 46(11):668-72. PubMed ID: 20796185.
    Abstract:
    AIM: To analyse the bacterial pathogens and drug sensitivities for neonatal community-acquired pneumonia. METHODS: Seven hundred sixty sputum samples from newborns with community-acquired pneumonia were cultured to determine microbial organisms present and their drug sensitivities. RESULTS: Of the 760 specimens, 425 grew pathogens for a 55.9% positive rate. Among the 425 positive cultures, 278 grew gram-negative organisms (65.4%), 142 grew gram-positive organisms (33.3%), while 5 grew fungus (1.3%). The most common gram-negative organisms were Escherichia coli, Klebsiella pneumoniae and Hemophilus influenzae, while the most common gram-positive organisms were Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus haemolyticus. To the gram-negative organisms, the most sensitive drugs were meropenem, imipenem and amikacin, while to the gram-positive ones were vancomycin, teicoplanin and quinupristin/dalfopristin. CONCLUSIONS: The most common causative bacteria were gram-negative organisms, which were highly sensitive to Meropenem, Imipenem and Amikacin, yet often treatable with more focused antibiotic coverage, which depended on the bacterium identified.
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