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  • Title: [Complex compounds of heparin with blood proteins and their natural inhibitors in splenectomy in animals].
    Author: Liapina LA, Kondashevskaia MV, Azieva LD, Soboleva GI.
    Journal: Patol Fiziol Eksp Ter; 1990; (4):20-2. PubMed ID: 2080078.
    Abstract:
    In depression of the function of the anticoagulating system after splenectomy in rats the blood serum heparin level diminishes, the fibrinogen concentration increases, the total and nonenzymatic fibrinolytic activity decreases, and the activity of some heparin complexes (adrenaline-heparin and serotonin-heparin) increases. A low-molecular protein inhibiting nonenzymatic fibrinolytic activity was isolated from blood plasma of splenectomized animals, some of its properties were studied. No such protein inhibitor was found in blood plasma of false-operated and intact rats.
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