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  • Title: Apoptosis: embedded in membranes.
    Author: Bogner C, Leber B, Andrews DW.
    Journal: Curr Opin Cell Biol; 2010 Dec; 22(6):845-51. PubMed ID: 20801011.
    Abstract:
    Many different signals for cell death converge on outer mitochondrial membrane permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and biochemical analyses emphasize that key regulatory interactions between different classes of Bcl-2 family members occur at and in intracellular membranes, and insertion into membranes causes functionally important conformational changes in the proteins.
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