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  • Title: Thermodynamic aspects of solubility process of some sulfonamides.
    Author: Perlovich GL, Ryzhakov AM, Strakhova NN, Kazachenko VP, Schaper KJ, Raevsky OA.
    Journal: J Pharm Biomed Anal; 2011 Jan 05; 54(1):222-4. PubMed ID: 20801596.
    Abstract:
    The thermodynamic aspects of solubility process of sulfonamides with the general structures C(6)H(5)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-Cl) and 4-NH(2)-C(6)H(4)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-CN; 4-Cl; 4-OMe; 4-C(2)H(5)) in water, phosphate buffer with pH 7.4 and n-octanol (as phases modeling various drug delivery pathways) were studied using the isothermal saturated method.
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