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  • Title: A doubly signal-amplified DNA detection method based on pre-complexed [Ru(bpy)3]2+-doped silica nanoparticles.
    Author: Bae SW, Cho MS, Hur SS, Chae CB, Chung DS, Yeo WS, Hong JI.
    Journal: Chemistry; 2010 Oct 11; 16(38):11572-5. PubMed ID: 20803581.
    Abstract:
    Easy detection: The target DNA in a 10-100 aM range can be detected by pre-complexed nanoparticles without additional amplification or target labeling. The [Ru(bpy)(3)](2+)-doped silica nanoparticles are hybridized to form a complex with highly enhanced sensitivity (see scheme). This method will be a significant improvement over conventional microarray/fluorescence readout systems.
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