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  • Title: Palladium-catalyzed carbonylative Heck-type reactions of alkyl iodides.
    Author: Bloome KS, Alexanian EJ.
    Journal: J Am Chem Soc; 2010 Sep 22; 132(37):12823-5. PubMed ID: 20804186.
    Abstract:
    A palladium-catalyzed carbonylative Heck-type cyclization of alkyl halides is described. Treatment of a range of primary and secondary alkyl iodides with catalytic palladium(0) under CO pressure forms a variety of synthetically versatile enone products. The reactivity described represents a rare example of a palladium-catalyzed Heck-type cyclization involving unactivated alkyl halides with β-hydrogens. Alkene substitution is well tolerated, and mono- and bicyclic carbocycles may be easily accessed.
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