These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The bioequivalence of intramuscular and subcutaneous administration of a formulation of oxytetracycline in the young bull].
    Author: Sanders P, Guillot P.
    Journal: Ann Rech Vet; 1990; 21 Suppl 1():57S-65S. PubMed ID: 2080848.
    Abstract:
    A bioequivalence study was performed in 6 bullocks to compare intramuscular (im) and subcutaneous (sc) routes for repeated treatments with an oxytetracycline formulation. Basic pharmacokinetic parameters were determined after a 10 mg/kg intravenous administration. Bioavailabilities for both im et sc routes were close to 85%. The pharmacokinetic parameters were used to perform an analysis of variance, and to determine the 95% confidence intervals and Westlake symmetrical confidence intervals. The two routes were significantly different regarding maximum concentration. The following symmetrical confidence intervals were calculated: area under the curve (+/- 20%), minimum concentration (+/- 51.5%), period during which plasma concentration was above 1 microgram/ml (+/- 25%). The two routes were bioequivalent for the area under curve.
    [Abstract] [Full Text] [Related] [New Search]