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  • Title: The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
    Author: Bonner MF, Ash S, Grossman M.
    Journal: Curr Neurol Neurosci Rep; 2010 Nov; 10(6):484-90. PubMed ID: 20809401.
    Abstract:
    Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.
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