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  • Title: Severe pertussis in infants: estimated impact of first vaccine dose at 6 versus 8 weeks in australia.
    Author: Foxwell AR, McIntyre P, Quinn H, Roper K, Clements MS.
    Journal: Pediatr Infect Dis J; 2011 Feb; 30(2):161-3. PubMed ID: 20811313.
    Abstract:
    We estimated the potential benefits of advancing the first dose of pertussis vaccine for infants from 8 to 6 weeks of age, using Australian national disease databases. Infants had notification rates 3-fold greater than the general population and accounted for 52% of recorded hospitalizations. Infants 1 and 2 months of age had notification rates 3.5 times (95% CI: 2.7-4.5) higher than infants 3 to 11 months of age. Estimation of acceleration of the vaccine to 6 weeks of age reduced average notifications, hospitalizations, and hospital bed-days by 8%, 9%, and 12%, respectively, with larger reductions in an epidemic year.
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