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  • Title: Isothermal sensitive detection of microRNA using an autonomous DNA machine recycling output as input.
    Author: Ogawa A.
    Journal: Bioorg Med Chem Lett; 2010 Oct 15; 20(20):6056-60. PubMed ID: 20813525.
    Abstract:
    An autonomous DNA machine recycling the output as the input for isothermal, sensitive, and specific detection of miRNAs has been developed. This machine shows considerably high signal amplification efficiency (∼1000-fold) and thus a low detection limit (∼20 amol). The machine also shows high specificity, discriminating 50 amol of synthetic miRNA from 100-fold larger amounts of its family member and from 100 ng of unrelated total RNAs. Moreover, it is available for practically detecting natural miRNAs in total RNAs.
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