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  • Title: [Association of CTLA4 gene +49G/A polymorphism with HBV infection and HBV-related hepatocellular carcinoma in Hunan Han population].
    Author: Liu G, Lu GX.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2010 Aug; 30(8):1838-40. PubMed ID: 20813679.
    Abstract:
    OBJECTIVE: To investigate the relationship between CTLA4 +49G/A SNP polymorphism and the susceptibility to hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: CTLA4+49G/A single nucleotide polymorphism (SNP) was analyzed by DNA sequencing in 165 control subjects, 155 patients with chronic hepatitis B (CHB) and 149 HCC patients. Serum HBsAg, HBeAg and AFP levels were measured in all the subjects. RESULTS: In HCC and CHB groups, the genotype frequency was 40.3% and 50.0% for GG , and 59.7% and 50.0% for AG+AA, respectively, while the genotype frequency was 61.8% for GG and 38.2% for AG+AA in the control group. In HCC group, CHB group and controls, the A allele frequencies was 44.6%, 37.4% and 28.8%, and the G allele frequencies was 55.4%, 62.6% and 71.2%, respectively. Significant differences were found not only in the allele frequencies (P<0.05) but also in AA and combined (AA+AG) genotype frequencies (P<0.05) between the 3 groups. CONCLUSION: +49G/A SNP of the CTLA4 gene can be associated with HBV and HBV-related HCC.
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