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  • Title: [Ingredients of Shuanghuanglian injection powder permeation through placental barrier of rat in pregnancy].
    Author: Song D, Guo J, Wang Y, Pan G, Li P, Zhang W, Song H.
    Journal: Zhongguo Zhong Yao Za Zhi; 2010 Jun; 35(12):1626-9. PubMed ID: 20815222.
    Abstract:
    OBJECTIVE: Use HPLC to study the permeation of ingredients of Shuanghuanglian injection powder (SHL) through placental barriers of rats at different stages of pregnancy. METHOD: The pregnant rats were administered SHL for 5 d through caudalis vena at different stages of pregnancy. Plasma and embryonic tissues were obtained 12 h after the final administration of SHL. The componds in biological specimen were identified by HPLC. RESULT: Baicalin, luteolin and wogonoside were the main compounds in plasma. Wogonoside retained in first trimester embryonic tissues, and baicalin retained in the embryonic tissues of different pregnant stages. CONCLUSION: Baicalin is the main compound of SHL through placental barriers of rats. Embryotoxicity of baicalin should be considered as the key point to evaluate the safety of SHL.
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