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  • Title: Magnetic resonance imaging for detection of brain abnormalities in fetuses with cleft lip and/or cleft palate.
    Author: Rosen H, Chiou GJ, Stoler JM, Mulliken JB, Tarui T, Meara JG, Estroff JA.
    Journal: Cleft Palate Craniofac J; 2011 Sep; 48(5):619-22. PubMed ID: 20815717.
    Abstract:
    OBJECTIVE: To determine the prevalence of brain abnormalities identified by prenatal imaging of fetuses with cleft lip with or without cleft palate (CL/P) or cleft palate only (CP) and to compare with postnatal imaging and neurologic evaluation. DESIGN: This was a retrospective review of radiologic images (magnetic resonance imaging [MRI] and sonography) of fetuses diagnosed with CL/P or CP at the Advanced Fetal Care Center at Children's Hospital Boston between 2002 and 2008. Images were reviewed for possible brain abnormalities by a pediatric radiologist who specializes in this field. Postnatal imaging was also assessed whenever available and correlated with clinical findings. SETTING: A large, tertiary-care, academic pediatric hospital. POPULATION: One hundred twenty-six fetuses and 105 corresponding infants. RESULTS: Brain abnormalities were found in 8 of 126 fetuses (6.3%) by prenatal MRI. The malformations were corpus callosal dysgenesis (n = 3), encephalocele (n = 1), hypoplasia of the cerebellar hemispheres or vermis (n = 3), and white matter neuronal migration anomaly (n = 1). An additional 2 patients were diagnosed with brain abnormalities postnatally that had not been detected on prenatal imaging. CONCLUSIONS: The possibility of brain anomalies should be assessed in a fetus found to have CL/P or CP by sonography and/or MRI. Central nervous system imaging and careful neurodevelopmental follow-up is indicated in these infants.
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