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  • Title: [Clinical significance of determination of serum B7-H4 in patients with malignant hematologic diseases].
    Author: Wang XM, Hu GY, Liu W, Zheng SH, Lv J, Wang HM, Xu JF.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2010 Sep; 26(9):893-4. PubMed ID: 20815987.
    Abstract:
    AIM: To study the clinical significance of determination of serum B7-H4 in patients with malignant hematologic diseases. METHODS: Serum B7-H4 levels were determined in 65 patients with leucemia, 34 patients with lymphoma, 12 patients with multiple myeloma as well as in 50 healthy controls. RESULTS: The serum B7-H4 levels in patients with lymphoma [(38.81+/-10.34) kappag/L] were significantly higher than healthy controls [(31.62+/-9.850) kappag/L] (P<0.01). But there are no significant difference of B7-H4 levels in serum among patients with leucemia, patients with multiple myeloma and healthy controls. CONCLUSION: These results suggest that the B7-H4 may correlated with lymphoma, but uncorrelated with leucemia and multiple myeloma. Measurement of serum B7-H4 level provide useful information for distinctive diagnosis of different kinds of malignant hematologic diseases.
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