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  • Title: Determination of tretinoin in creams by high-performance liquid chromatography.
    Author: Kril MB, Burke KA, DiNunzio JE, Gadde RR.
    Journal: J Chromatogr; 1990 Nov 28; 522():227-34. PubMed ID: 2081753.
    Abstract:
    A stability indicating reversed-phase high-performance liquid chromatographic method has been developed to quantify tretinoin (all-trans-retinoic acid) in cream formulations. Tretinoin cream samples were dissolved directly in tetrahydrofuran and diluted for injection. Separation was accomplished on a 15 cm Nova-Pak C18 column using a tetrahydrofuran-phosphate buffer solvent system (42:58, v/v) and 1.0 ml/min flow-rate. The method is able to separate tretinoin from its degradation products formed under stressing conditions. Excellent precision and accuracy were found for the assay of tretinoin in the cream formulations.
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