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  • Title: Pyrimidine based highly sensitive fluorescent receptor for Al3+ showing dual signalling mechanism.
    Author: Upadhyay KK, Kumar A.
    Journal: Org Biomol Chem; 2010 Nov 07; 8(21):4892-7. PubMed ID: 20820652.
    Abstract:
    A new fluorescent probe (5-[(4-diethylamino-2-hydroxy-benzylidene)-amino]-1H-pyrimidine-2, 4-dione) (Receptor 1) has been synthesized by the Schiff base condensation of 5-aminouracil with 4-(diethylamino)salicylaldehyde. The receptor 1 exhibits high selectively for Al(3+) in DMSO as well as in aqueous solution even in the presence of biologically relevant cations such as Na(+), K(+), Ca(2+), Mg(2+), Pb(2+) and several transition metal ions. The lowest detection limit for the receptor 1 was found to be 1.62 × 10(-10) M with its linear response towards Al(3+) in the concentration range of 1.75 × 10(-9) to 3.3 × 10(-8) M in DMSO. Receptor 1 is the first ever example where a single molecular probe is able to show imine (C=N) isomerization inhibition along with twisted intramolecular charge transfer (TICT) in combinatorial fashion.
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