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  • Title: Cumulative cardiac toxicity of sodium stibogluconate and amphotericin B in treatment of kala-azar.
    Author: Maheshwari A, Seth A, Kaur S, Aneja S, Rath B, Basu S, Patel R, Dutta AK.
    Journal: Pediatr Infect Dis J; 2011 Feb; 30(2):180-1. PubMed ID: 20823781.
    Abstract:
    Kala-azar or visceral leishmaniasis is a disseminated protozoal infection caused by parasites of the genus Leishmania (Leishmania donovani in India). Conventional therapy for visceral leishmaniasis continues to be pentavalent antimony (sodium antimony gluconate [SAG]). Amphotericin B is widely used for SAG-unresponsive cases and sometimes even as a first-line drug, especially in endemic areas. With the conventional regimen of SAG, cardiac toxicity has been reported in 8% to 17% of cases with 5% to 7% of them having fatal toxicity. Cardiac toxicity is uncommon with amphotericin B with only few isolated reports. We report some patients with kala-azar in whom coadministration of SAG and amphotericin B led to arrhythmia and sudden death.
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