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  • Title: Differential responses of human microglia and blood-derived myeloid cells to FTY720.
    Author: Durafourt BA, Lambert C, Johnson TA, Blain M, Bar-Or A, Antel JP.
    Journal: J Neuroimmunol; 2011 Jan; 230(1-2):10-6. PubMed ID: 20826007.
    Abstract:
    Human microglia, monocyte-derived dendritic cells (DCs) and macrophages ex vivo express relatively higher levels of sphingosine-1-phosphate (S1P) receptor 1 (S1P1) mRNA as compared to other receptor subtypes. The S1P agonist FTY720 decreased ERK phosphorylation and induced myosin light chain (MLC) II phosphorylation only in macrophages and DCs. FTY720 inhibited IL-12p70 production (CD40L induced) by DCs and macrophages but not microglia (poly I:C induced). IL-10 production was increased in DCs and unaffected in other myeloid cells. Despite similar receptor expression patterns, the distinct myeloid cell populations present in the human CNS, under steady-state or inflammatory conditions, exhibit differential responses to FTY720.
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