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  • Title: Expression of aquaporin-1 in nasopharyngeal cancer tissues.
    Author: Li Q, Zhang B.
    Journal: J Otolaryngol Head Neck Surg; 2010 Oct; 39(5):511-5. PubMed ID: 20828513.
    Abstract:
    OBJECTIVE: To investigate the expression of aquaporin-1 (AQP1) in nasopharyngeal tumour and nontumour tissues. METHOD: Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative polymerase chain reaction (RT-PCR) to detect the expression level of AQP1 in tissues. RESULTS: Immunohistochemistry data suggested that AQP1 was expressed in both nasopharyngeal tumour and normal tissues, but tumour tissues were stained a lot stronger than nontumour tissues. RT-PCR analysis further confirmed the overexpression of AQP1 in tumour tissues; migrated tumour tissue had even higher expression. CONCLUSION: The expression level of aquaporin-1 in nasopharyngeal cancer tissue could be involved in tumour migration.
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